Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.998 0.482 0.354
biological_process el 70 0.0 1.0 0.971 0.166
biological_process ka 70 0.0 1.0 0.971 0.166
biological_process node2vec 70 0.0 0.98 0.481 0.263
biological_process rf 70 0.0 1.0 0.971 0.166
cellular_component ct 71 0.0 1.0 0.451 0.308
cellular_component el 71 0.0 1.0 0.881 0.314
cellular_component ka 71 0.0 1.0 0.944 0.23
cellular_component node2vec 71 0.0 0.978 0.463 0.309
cellular_component rf 71 0.0 1.0 0.879 0.318
disease ct 25 0.0 1.0 0.412 0.339
disease el 25 0.001 1.0 0.8 0.399
disease ka 25 0.001 1.0 0.96 0.196
disease node2vec 25 0.001 0.871 0.437 0.284
disease rf 25 0.001 1.0 0.8 0.399
genetic_interaction_weighted ct 73 0.0 0.997 0.318 0.299
genetic_interaction_weighted el 73 0.0 1.0 0.421 0.393
genetic_interaction_weighted ka 73 0.0 1.0 0.945 0.227
genetic_interaction_weighted node2vec 73 0.0 0.986 0.404 0.299
genetic_interaction_weighted rf 73 0.0 1.0 0.384 0.353
molecular_function ct 71 0.0 1.0 0.591 0.328
molecular_function el 71 0.0 1.0 0.874 0.33
molecular_function ka 71 0.0 1.0 0.93 0.255
molecular_function rf 71 0.0 1.0 0.874 0.332
pathway ct 30 0.985 1.0 0.998 0.004
pathway el 30 0.001 1.0 0.834 0.372
pathway ka 30 0.001 1.0 0.834 0.37
pathway node2vec 30 0.0 0.953 0.462 0.311
pathway rf 30 0.001 1.0 0.834 0.371
phenotype ct 26 0.006 1.0 0.615 0.365
phenotype el 26 0.0 1.0 0.769 0.421
phenotype ka 26 0.0 1.0 0.923 0.266
phenotype node2vec 26 0.0 0.98 0.449 0.342
phenotype rf 26 0.0 1.0 0.769 0.421
protein_interaction ct 73 0.0 0.777 0.037 0.129
protein_interaction el 73 0.0 0.681 0.034 0.115
protein_interaction ka 73 0.001 1.0 0.347 0.472
protein_interaction node2vec 73 0.001 0.838 0.057 0.146
protein_interaction rf 73 0.0 0.647 0.033 0.109

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 1.0 0.298 0.287
integration_mean_by_presence el 73 0.0 0.651 0.025 0.087
integration_mean_by_presence ka 73 0.0 1.0 0.332 0.468
integration_mean_by_presence rf 73 0.0 0.697 0.046 0.112
mean ct 73 0.0 1.0 0.287 0.312
mean el 73 0.0 0.632 0.025 0.085
mean ka 73 0.0 1.0 0.332 0.468
mean rf 73 0.0 0.604 0.036 0.087

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels